Platelet factor 3 in normal subjects and patients with renal failure

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Platelet Factor 3 in Normal Subjects and Patients with Renal Failure

Two tests were used to differentiate abnormalities in release of platelet factor 3 (PF3) from quantitative deficiencies of this factor in normal subjects and in patients with renal failure. The first test was an assay which determined availability of PF3 (PF3-A time) and involved the use of a mixture of patient's plateletrich plasma (PRP) and normal platelet-poor plasma (PPP) in a fixed ratio (...

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Platelet factor 3 in normal subjects and patients with renal failure.

Two tests were used to differentiate abnormalities in release of platelet factor 3 (PF3) from quantitative deficiencies of this factor in normal subjects and in patients with renal failure. The first test was an assay which determined availability of PF3 (PF3-A time) and involved the use of a mixture of patient's platelet-rich plasma (PRP) and normal platelet-poor plasma (PPP) in a fixed ratio ...

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Amoxycillin: pharmacokinetic studies in normal subjects, patients with pernicious anaemia and those with renal failure.

This paper presents data on the absorption and disappearance of a new semisynthetic antibioticamoxycillin-in patients with pernicious anaemia and those with renal failure. Absorption of this drug is unimpaired in these patients. Adequate serum and urine levels are obtained even in patients with creatinine clearance levels below 10 ml/min. The half-life of this drug is markedly prolonged in pati...

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A studyof the pharmacokinetics of clidamycin in normal subjects and patients with chronic renal failure.

A single dose of 150 mg clindamycin was given to nine patients with terminal renal failure being treated by maintenance haemodialysis and the blood levels were measured. Four of these patients were studied during haemodialysis and five between haemodialyses. Clindamycin (150 mg) was also given orally to four normal subjects. The mean serum half-life in the normal subjects was 2-15 hr. For the d...

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ژورنال

عنوان ژورنال: Journal of Clinical Investigation

سال: 1968

ISSN: 0021-9738

DOI: 10.1172/jci105782